
Healthcare · Volume 1 of the Equation Series
The Care Equation
How Healthcare Companies Create, Capture and Destroy Value
By Thomas Kofi Annan · First edition, 2026
Healthcare is the largest industry in the world and one of the hardest in which to build a business. 3 trillion on health in 2024, nearly a fifth of its economy. Read more
- 25
- chapters
- 24
- industry studies
- 100
- companies
- 881
- moves
Complete EditionBest value
Everything above, at the best price
PDF + EPUB + M4B
$99
The Book
25 chapters · ~51,000 words
PDF + EPUB, plus the narrative edition
$29
Research Companion
24 studies · 100 profiles · 881 moves · ~1.5 million words
PDF + EPUB, plus the narrative edition
$59
Audiobook
158 hr 25 min across 4 volumes
M4B (chaptered)
$39
From the preface
The care equation
Healthcare is the largest industry in the world and one of the hardest in which to build a business. The United States alone spent about $5.3 trillion on health in 2024, nearly a fifth of its economy. Some companies have turned that spending into lasting value: integrated systems that keep their members healthier, devices that changed how surgery and diabetes are managed, drugs that reshaped whole diseases, and, in places such as India and West Africa, models that bring care to people the system had left out. Many more have not. Well-funded start-ups have built products that clinicians would not use, programmes whose savings vanished under a randomised trial, insurers whose growth outran their underwriting, and roll-ups whose profits came from a gap in a payment formula until someone closed it. Some of the most admired companies in other industries tried to fix healthcare and left within three years.
The difference is rarely the technology alone. This book argues that a healthcare business creates durable value only when four things are true at once, and that the factors multiply rather than add: if any is zero, the result is zero. The care must improve health or lower its cost. There must be a payer willing and able to pay for it, from a budget that renews. The company must be able to reach that payer for less than the payer is worth. And the proof must be strong enough to survive contracting and regulation. Around those four factors sit two forces that no company controls, reimbursement policy and capital cycles, which behave like weather: they do not decide whether care works, but they decide how long a company has to show that it does. In healthcare the patient is rarely the buyer, the person who chooses is often the clinician, and the payer is usually an insurer, an employer or a government. Most of the failures in this book come from treating one of the four factors as given rather than earned.
The twenty-five chapters develop that view. Part I sets out why healthcare is not a normal market, how it became a business, how money flows from premiums and taxes to hospitals, doctors, insurers and drugmakers, and how value and evidence are judged. Part II follows the markets one by one: hospitals, physicians and outpatient care, insurers, government as payer, drugs and the pharmacy chain, devices and diagnostics, and care in the home and for the mind. Part III examines what it takes to build products that work, from the electronic record and digital health to artificial intelligence, business models, selling into healthcare and value-based care. Part IV covers investing, private equity and consolidation, regulation and privacy, prices and reform, and health systems around the world. Part V turns to people: the clinical workforce and how to build a healthcare company and its team. Part VI reads five cases for the decisions behind them. Each chapter opens with a case, explains the mechanics it illustrates, and closes by naming the factor of the equation on which its case turned.
The book · ~51,000 words
Contents
Each chapter has a free preview of its opening and section list.
Part I
Foundations
Part II
The Markets
Part III
Building What Works
Part IV
Scaling, Capital, and Rules
Practical Reference
Appendices
- AWorked Healthcare Examples
- BTools and Checklists
- CGlossary
- DSources and the Research Companion
Healthcare Research Companion · Part I
24 industry studies
The companion opens with an in-depth study of each part of the industry, backed by 26 technical exhibits: worked examples, diligence checklists and case studies.
Healthcare Research Companion · Part II
100 companies, 881 strategic moves
A profile of each company, followed by its defining moves year by year from 1833 to 2026: what was decided, why, how it was financed, and what happened next.
- Abbott Laboratories8
- AbbVie Inc.8
- Abridge AI, Inc.9
- Accolade, Inc.9
- agilon health, inc.9
- Aledade, Inc.9
- Amazon Health (Amazon Health Services)9
- Amedisys, Inc.8
- Amwell (American Well Corporation)9
- Apollo Hospitals Enterprise Limited9
- Apple Health (Apple Inc.'s health business)9
- Ascension9
- athenahealth, Inc.9
- Babylon Holdings Limited (Babylon Health)9
- Blue Cross Blue Shield (the Association and the Blue plans)10
- Bright Health Group (NeueHealth, Inc.)10
- Brookdale Senior Living Inc.10
- Butterfly Network, Inc.8
- Cano Health, Inc.9
- Cardinal Health, Inc.9
- Cencora, Inc. (formerly AmerisourceBergen)9
- Centene Corporation9
- Cerebral, Inc.10
- Change Healthcare (now part of Optum, UnitedHealth Group)8
- ChenMed, LLC8
- Cleveland Clinic9
- Clover Health Investments, Corp.9
- CommonSpirit Health9
- Community Health Systems, Inc. (CHS)10
- CVS Health Corporation9
- DaVita Inc.10
- Devoted Health, Inc.9
- Dexcom, Inc.9
- Discovery Limited — Discovery Health and Vitality9
- Doximity, Inc.9
- Elevance Health, Inc. (formerly Anthem and WellPoint)8
- Eli Lilly and Company8
- Envision Healthcare Corporation8
- Epic Systems Corporation10
- Fresenius Medical Care AG9
- GE HealthCare Technologies Inc.8
- GoodRx Holdings, Inc.9
- Google Health and Verily (Alphabet's healthcare businesses)9
- HCA Healthcare, Inc.9
- Hims & Hers Health, Inc.9
- Hinge Health, Inc.9
- Humana Inc.9
- IBM Watson Health (now Merative)10
- Intermountain Health10
- Intuitive Surgical, Inc.8
- Johnson & Johnson8
- Kaiser Permanente9
- Kindred Healthcare (formerly Vencor)9
- Koninklijke Philips N.V. (Royal Philips)8
- Labcorp Holdings Inc.8
- Lyra Health, Inc.8
- Mark Cuban Cost Plus Drug Company, PBC7
- Mayo Clinic10
- McKesson Corporation9
- Medtronic plc8
- Merck & Co., Inc.8
- Microsoft Nuance (Nuance Communications, a Microsoft company)10
- Molina Healthcare, Inc.9
- mPharma10
- Narayana Health (Narayana Hrudayalaya Ltd)9
- NHS England10
- Noom, Inc.9
- Novo Nordisk A/S8
- Oak Street Health8
- Omada Health, Inc.9
- One Medical (1Life Healthcare, Inc.; Amazon One Medical)8
- Oracle Health (formerly Cerner Corporation)9
- Oscar Health, Inc.9
- Pfizer Inc.8
- Ping An Good Doctor (Ping An Healthcare and Technology Company Limited)9
- Privia Health Group, Inc.10
- Purdue Pharma L.P.8
- Quest Diagnostics Incorporated8
- R1 RCM Inc. (formerly Accretive Health)8
- Rite Aid Corporation8
- Ro (Roman Health Ventures Inc.)8
- Roche Holding AG8
- Siemens Healthineers AG8
- Steward Health Care System LLC10
- Stryker Corporation8
- Talkspace, Inc.9
- Teladoc Health, Inc.10
- Tempus AI, Inc.9
- Tenet Healthcare Corporation9
- The Cigna Group8
- Theranos, Inc.8
- UnitedHealth Group Incorporated9
- Veeva Systems Inc.9
- VillageMD (Village Practice Management Company, LLC)8
- Viz.ai, Inc.9
- Walgreens Boots Alliance, Inc.9
- Walmart Health (Walmart Inc.'s healthcare business)8
- Waystar Holding Corp.9
- Zipline International Inc.10
- Zocdoc, Inc.8
Audiobook & narrative editions
158 hr 25 min of narration
Both volumes are rewritten as narrative editions that read straight through, in long-form prose instead of tables. The audiobook is narrated from those editions as chaptered M4B files that play in Apple Books, VLC, BookPlayer and most audiobook apps.
- The Book16 hr 16 min
- Companion Volume 1 - Industry Studies20 hr 6 min
- Companion Volume 2 - Companies A to I61 hr 19 min
- Companion Volume 3 - Companies I to Z and Timeline60 hr 44 min
Appendix C
Glossary: 43 terms
- 340B
- A federal programme requiring drug manufacturers to sell outpatient drugs at steep discounts to eligible hospitals and clinics, which may bill insurers at higher rates.
- ACO
- Accountable care organisation: a group of providers that shares in savings, and sometimes losses, against a spending benchmark for a population.
- Anti-Kickback Statute
- The federal criminal law that prohibits paying or receiving anything of value to induce referrals of business paid by federal health programmes.
- ASO
- Administrative services only: an arrangement in which a self-insured employer pays claims and an insurer is paid a fee for network and administration.
- AWP
- Average wholesale price: a list-based benchmark used to set pharmacy reimbursement.
- CAC
- Customer acquisition cost: the cost of winning and launching a customer.
- Capitation
- A fixed payment per person per period to cover a defined set of services, transferring cost risk to the recipient.
- Coding intensity
- The tendency of risk scores in Medicare Advantage to rise faster than underlying morbidity because of more complete or more aggressive diagnosis coding.
From the blog
Read before you buy
Complete guide
How the Healthcare Industry Makes Money: A Complete Guide
Who pays for US healthcare, how hospitals, insurers, PBMs, drugmakers and doctors get paid, and where the profit settles in a $5.3 trillion system.
15 min read
Explainer
How Do Medicare Advantage Plans Make Money? The Formula Explained
Medicare Advantage plans earn the gap between a risk-adjusted federal payment and members' care costs. Here is how benchmarks, bids, stars and coding work.
8 min read
Explainer
How Do PBMs Make Money? Rebates, Spreads and Fees Explained
Pharmacy benefit managers earn from retained rebates, spread pricing, owned pharmacies and fees. Here is how each works, with one prescription traced.
9 min read
The Care Equation
Learn the framework from the book. Test it against the companion.
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